Dorsal language stream anomalies in an inherited speech disorder
نویسندگان
چکیده
منابع مشابه
Neural basis of an inherited speech and language disorder.
Investigation of the three-generation KE family, half of whose members are affected by a pronounced verbal dyspraxia, has led to identification of their core deficit as one involving sequential articulation and orofacial praxis. A positron emission tomography activation study revealed functional abnormalities in both cortical and subcortical motor-related areas of the frontal lobe, while quanti...
متن کاملBehavioural analysis of an inherited speech and language disorder: comparison with acquired aphasia.
Genetic speech and language disorders provide the opportunity to investigate the biological bases of language and its development. Critical to these investigations are the definition of behavioural phenotypes and an understanding of their interaction with epigenetic factors. Here, we report our investigations of the KE family, half the members of which are affected by a severe disorder of speec...
متن کاملMRI analysis of an inherited speech and language disorder: structural brain abnormalities.
Analyses of brain structure in genetic speech and language disorders provide an opportunity to identify neurobiological phenotypes and further elucidate the neural bases of language and its development. Here we report such investigations in a large family, known as the KE family, half the members of which are affected by a severe disorder of speech and language, which is transmitted as an autos...
متن کاملAn extended family with a dominantly inherited speech disorder.
A three-generation family is described in which 16 members have a severe developmental verbal dyspraxia. Inheritance is autosomal dominant, with full penetrance. Intelligence and hearing are normal.
متن کاملThe dorsal stream in speech processing: Model and theory
The ability to produce and comprehend spoken language requires an internal understanding of the complex relations between articulatory gestures and their acoustic consequences. Recent theories of speech processing propose a division between the ventral stream, which involves the mapping of acoustic signals to lexical/semantic representations, and the dorsal stream, which mediates the mapping be...
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ژورنال
عنوان ژورنال: Brain
سال: 2019
ISSN: 0006-8950,1460-2156
DOI: 10.1093/brain/awz018